CD203c in patients with cystic fibrosis and allergy to Aspergillus fumigatus
نویسندگان
چکیده
منابع مشابه
Tests to Assess Sensitization to Aspergillus Fumigatus in Cystic Fibrosis
OBJECTIVE To evaluate the results of the tests used to identify the IgE mediated sensitization to Aspergillus fumigatus in patients with cystic fibrosis. METHODS This is a cross-sectional descriptive study with a convenience sample of 86 patients diagnosed with cystic fibrosis in the Reference Service in Cystic Fibrosis at a tertiary teaching hospital. The following tests were performed to as...
متن کاملThe basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis.
BACKGROUND Colonization by Aspergillus fumigatus in patients with cystic fibrosis (CF) can cause A fumigatus sensitization and/or allergic bronchopulmonary aspergillosis (ABPA), which affects pulmonary function and clinical outcomes. Recent studies show that specific allergens upregulate the surface-expressed basophil marker CD203c in sensitized subjects, a response that can be readily measured...
متن کاملIgG antibodies to Aspergillus fumigatus in cystic fibrosis.
Serum was collected from 50 patients with cystic fibrosis, and IgG antibodies to Aspergillus fumigatus were measured by enzyme linked immunosorbent assay (ELISA). In addition, total IgE and Aspergillus specific IgE antibodies were measured in 41 of the 50. A close association was found between pulmonary function and clinical state, and IgG antibodies to Aspergillus. There was no association bet...
متن کاملSpecific antibodies to recombinant allergens of Aspergillus fumigatus in cystic fibrosis patients with ABPA
BACKGROUND Aspergillus fumigatus, a widely distributed fungus, has been implicated in causing life threatening infections as well as severe asthma and allergic diseases in man. Allergic affliction like allergic bronchopulmonary aspergillosis (ABPA) is a disabling lung disease frequently seen in patients with asthma and cystic fibrosis. Immunodiagnosis of the former is comparatively easier due t...
متن کاملSerologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis.
OBJECTIVES The objectives of this study were to determine the prevalence of Aspergillus fumigatus and Candida albicans in the sputa of patients with cystic fibrosis (CF), to assess serologic IgE responses of these patients to the presence of fungi in the sputum, to evaluate what effect this may have on clinical status, and to determine how the above-mentioned factors relate to allergic bronchop...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2016
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2015.11.014